PR (Progesterone Receptor)

Purpose

Detection and quantification of progesterone receptor in breast cancer carcinomas.

Services

AQUA staining multiplexed with cytokeratin

Introduction

The progesterone receptor (PR) is an intracellular steroid receptor that specifically binds progesterone. The absence of PR in breast cancer predicts early recurrence and poor survival of patients. The presence of PR (together with ER) is an indicator for targeted endocrine therapy (like tamoxifen).

Specificity

Reactions are found with both free and hormone-bound PR.

Staining Interpretation

The PR staining pattern is nuclear, with scoring possible (a positive staining is defined as  more than 10% of cells with stained nuclei of any intensity).

Description

Thomas Jefferson Kimmel Cancer Center

Rui Lab